Scientific Publications Acknowledged MMAAP Foundation’s SupportEnglish PublicationsChinese PublicationsThe Irma and Paul Milstein Program for Senior Health: 40Jintang Wang, Zheng Chen, Sean X. Leng. Interferon-γ potentiates α-synuclein-induced neurotoxicity linked to toll-like receptor 2 & 3 and tumor necrosis factor-α in murine astrocytes. Molecular Neurobiology, (accepted).Juliette Tavenier, Joseph B. Margolick, Sean X. Leng. T-cell immunity against cytomegalovirus in HIV infection and aging: relationships with inflammation, immune activation, and frailty. Medical Microbiology and Immunology, (accepted).Juliette Tavenier, Sean X. Leng. Inflammation pathways to anemia in frail older adults. Clinics in Geriatric Medicine, (accepted).Sean X. Leng, Haiyan Zhang, Linda P. Fried. Inflammatory Markers and Frailty. Handbook of Immunosenescence, 2019: 1-14.Yiyin Chen, Sally Liu, Sean X. Leng. Chronic Low-grade Inflammatory Phenotype (CLIP) and Senescent Immune Dysregulation. Clinical Therapeutics, 2019 (Article in Press).Jintang Wang, Yuetao Song, Zheng Chen, Sean X. Leng. Connection between Systemic Inflammation and Neuroinflammation Underlies Neuroprotective Mechanism of Several Phytochemicals in Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity, 2018; 2018: 1-16.Sean X. Leng, Xiaoying Li. Introduction of Abstracts to be Presented at the Seventh Chinese Congress on Gerontology and Health Industry. Journal of the American Geriatric Society, 2018; 66: s441- s442.Waijiao Cai, Danielle Feng, Michael A. Schwarzschild, Pamela J. McLean, Xiqun Chen. Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice. EBioMedicine, 2018; 29: 13–22.Xin Li, Li Fan, Sean X. Leng. The Aging Tsunami and Senior Healthcare Development in China. Journal of American Geriatrics Society, 2018; 66 (8): 1462 – 1468.Maryam Keshtkar-Jahromi, Min Ouyang, Marzieh Keshtkarjahromi, Samah Almed, Huifen Li, Jeremy D. Walson, Rebeca Rios, Sean X. Leng. Effect of influenza vaccine on Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults. Vaccine, 2018; 36 (16): 2220 – 2225.Jintang Wang, Zheng Chen, Jeremy D. Walson, Peisong Gao, Maolong Gao, Sean X. Leng. α-Synuclein activates innate immunity but suppresses interferon-γ expression in murine astrocytes. European Journal of Neuroscience, 2018:1–17.Joseph B. Margolick, Jay H. Bream, Tricia L. Nilles, Huifen Li, Susan J. Langan, Shane Deng, Ruibin Wang, Nikolas Wada, Sean X. Leng. Relationship between T-Cell Responses to CMV, Markers of Inflammation, and Frailty in HIV-uninfected and HIVinfected Men in the Multicenter AIDS Cohort Study. The Journal of Infectious Diseases, 2018; 218 (2): 1-10.Jinlei Li, Matthew Ogrodnik, Vijaya B. Kolachalamad, Honghuang Lin, Rhoda Au. Assessment of the Mid-Life Demographic and Lifestyle Risk Factors of Dementia Using Data from the Framingham Heart Study Offspring Cohort. Journal of Alzheimer’s Disease, 2018; 63 (3):1119–1127.Jinlei Li, Matthew Ogrodnik, Sherral Devine, Sanford Auerbach, Philip A. Wolf, Rhoda Au. Practical risk score for 5-, 10-, and 20-year prediction of dementia in elderly persons: Framingham Heart Study. Alzheimer’s & Dementia, 2018; 14 (1): 35 – 42.Xiang Ding, Yong He, Qiukui Hao, Shanping Chen, Ming Yang, Sean X. Leng, Jirong Yue, Birong Dong. The association of single nucleotide polymorphism rs189037C>T in ATM gene with coronary artery disease in Chinese Han populations: A case control study. Medicine, 2018; 97(4) : e9747Jing Tang, Hans B. Liu, Lujiao Yu, Xin Meng, Sean X. Leng, Haiyan Zhang. Clinical-pathological Characteristics and Prognostic Factors for Papillary Thyroid Microcarcinoma in the Elderly. Journal of Cancer, 2018; 9 (2): 256–262.Junhong Zhou, On-Yee Lo, Lewis A. Lipsitz, Jue Zhang, Jing Fang, Brad Manor. Transcranial direct current stimulation enhances foot sole somatosensation when standing in older adults. Experimental Brain Research, 2018; 236 (3):795-802.Jintang Wang, Sean X. Leng. Inflammation and its role in ageing and disease. Oxford Textbook of Geriatric Medicine, 2018(3).Xiqun Chen, Hongxiang Chen, Waijiao Cai, Michael Maguire, Bailiu Ya, Fuxing Zuo, Robert Logan, Hui Li, Katey Robinson, Charles R. Vanderburg, Yang Yu, Yinsheng Wang, David E. Fisher, Michael A. Schwarzschild. The Melanoma- Linked “Redhead” MC1R Influences Dopaminergic Neuron Survival. Annals of Neurology, 2017; 81(3):395–406.Xiang Ding, Qiukui Hao, Ming Yang, Tie Chen, Shanping Chen, Jirong Yue, Sean X. Leng, Birong Don. Polymorphism rs189037C > T in the promoter region of the ATM gene may associate with reduced risk of T2DM in older adults in China: a case control study. BMC Medical Genetics, 2017; 18 (84): 1-7.Xinwen Zhang, Xin Meng, Yiyin Chen, Sean X. Leng, Haiyan Zhang. The Biology of Aging and Cancer Frailty, Inflammation, and Immunity. The Cancer Journal, 2017; 23 (4): 201 – 205.Mingfang Zhao, Hans Liu, Yanqing Tang, Xin Meng, Jun Yu, Qi Wang, Qiao Zhou, Sean X. Leng, Haiyan Zhang. Clinicpathologic features and prognostic factors for patients with colorectal cancer who are 75 years and older. Oncotarget, 2017; 8 (45): 80002 – 80011.Sean X. Leng, Xiao Ying Li. Introduction of Abstracts to be Presented at the Sixth Chinese Congress on Gerontology and Health Industry. Journal of the American Geriatric Society, 2017; 65 (s2): s293- s294.Gregory D. Kirk, Stewart Dandorf, Huifen Li, Yiyin Chen, Shruti H. Mehta, Damani A. Piggott, Joseph B. Margolick, Sean X. Leng. Differential Relationships among Circulating Inflammatory and Immune Activation Biomediators and Impact of Aging and Human Immunodeficiency Virus Infection in a Cohort of Injection Drug Users. Frontiers in Immunology, 2017; 8:1343.Sean X. Leng, Jeremy Kamil, John G. Purdy, Niels A. Lemmermann, Matthias J. Reddehase, Felicia D. Goodrum. Recent advances in CMV tropism, latency, and diagnosis during aging. GeroScience, 2017; 39 (3): 251-259.Xiang Ding, Joseph B. Margolick, Sean X. Leng. T-Cell Immunity against Cytomegalovirus in Older Adults. Handbook of Immunosenescence, 2017: 1-14.Sean X. Leng, Xiaohong Liu, Jeffery B. Halter. A Chinese Home Care Model for Frail Elderly Integrating Geriatrics, Home Service, and Technology. Innovation in Aging, 2017; 1 (1): 1048–1049.Xiaohong Liu, Minglei. Zhu, Lin Kang. The Role of Geriatrics Interdisciplinary Team in Home Care for the Frail Elderly in Beijing, China. Innovation in Aging, 2017; 1 (1): 1049.Qianli Xue, Huanle Yang, Huifen Li, Peter M. Abadir, Tyesha N. Burks, Lauren G. Koch, Steven L. Britton, Joshua Carlson, Laura Chen, Jeremy D. Walston, Sean X. Leng. Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats. Aging, 2016; 8 (3): 769 – 776.Sean X. Leng, Xiaoying Li. Introduction of Abstracts to be Presented at the Fifth Chinese Congress on Gerontology and Health Industry. Journal of the American Geriatric Society, 2016; 64 (s2): s315- s316.Genxiang Mao, Huifen Li, Xiang Ding, Xin Meng, Guofu Wang, Sean X. Leng. Suppressive effects of sirtinol on human cytomegalovirus (hCMV) infection and hCMV-induced activation of molecular mechanisms of senescence and production of reactive oxygen species. Mechanisms of Ageing and Development, 2016; 158: 62 – 69.Huifen Li, Genxiang Mao, Joshua Carlson, Sean X. Leng. A novel flow cytometry-based tool for determining the efficiency of human cytomegalovirus infection in THP-1 derived macrophages. Journal of Virological Methods, 2015; 221 (1): 127 – 130.Jirong Yue, Tammy T. Hshieh, Sharon K. Inouye. Hospital Elder Life Program (HELP). Geriatrics Models of Care, 2015: 25-37. (book, doesn’t have volume and issue number )Sean X. Leng, Joseph B. Margolick. Understanding Frailty, Aging, and Inflammation in HIV Infection. Current HIV/AIDS Reports, 2015; 12 (1): 22 – 35.Sean X. Leng, Stewart Dandorf, Huifen Li, Joshua Carlson, Jessica Hui, Shruti H. Mehta, Damani Piggott, Salequl Islam, Bhavish Manwani, Gregory D Kirk. Associations of Circulating Soluble Tumor Necrosis Factor-α Receptors 1 and 2 with Interleukin-6 Levels in an Aging Cohort of Injection Drug Users with or at High Risk for HIV Infection. AIDS Research and Human Retroviruses, 2015; 31 (12): 1257-1264.Sean X. Leng, Xiaoying Li. Introduction of Abstracts to be Presented at the Fourth Chinese Congress on Gerontology and Health Industry. Journal of the American Geriatric Society, 2015; 63 (s2): s321- s322.Sean X. Leng, Jennie Chin Hansen, Xiaoying Li. Introduction of Abstracts to be Presented at the Third Chinese Congress on Gerontology and Health Industry. Journal of the American Geriatric Society, 2014; 62 (s2): s333- s334.Huifen Li, Peter Weng, Kevin Najarroa, Qianli Xue, Richard D.Sembab, Joseph Margolick, Sean X.Leng. Chronic CMV infection in older women: Longitudinal comparisons of CMV DNA in peripheral monocytes, anti-CMV IgG titers, serum IL-6 levels, and CMV pp65 (NLV)-specific CD8+ T-cell frequencies with twelve-year follow-up. Experimental Gerontology, 2014; 54: 84-89.Xujiao Chen, Genxiang Mao, Sean X Leng. Frailty syndrome: an overview. Clinical Interventions in Aging, 2014; 9: 433-441.Sean X. Leng, Jennie Chin Hansen, Xiaoying Li. Introduction of Abstracts to be Presented at the Second Chinese Congress on Gerontology and Health Industry. Journal of the American Geriatric Society, 2013; 61 (s3): s307- s308.Dermatology: 13Tian Zhu, Donglai Ma, Y.P. Zeng, L. Song, Li Li. Bullous pemphigoid associated with silicosis. Journal of the European Academy of Dermatology and Venereology, 2018; 32 (1): e1-e2.Yu Zhang, Yang Luo, Yue Han, Rong Tian, Wei Li, Xu Yao. Non-bullous lesions as the first manifestation of bullous pemphigoid: A retrospective analysis of 181 cases. The Journal of Dermatology, 2017 44(7): 742 -746.Luo, Jie Liu. Image Gallery: Verrucous porokeratosis with characteristic histopathological and dermoscopic feature. British Journal of Dermatology, 2017; 176 (4): e38.Chenchen Xu, Dan Zhou, Yixin Luo, Shuai Guo, Tao Wang, Jie Liu, Yuehua Liu and Zhili Li.Tissue and serum lipidome shows altered lipid composition with diagnostic potential in mycosis fungoides. Oncotarget, 2017; 8 (29): 48041 – 48050.Luo, Jie Liu. Image Gallery: Moth-eaten alopecia as the only cutaneous symptom of acquired secondary syphilis in a 2-year-old boy. British Journal of Dermatology, 2017; 177(5) : e227.Tian Zhu, Tao Wang, Dongkai Ma, Yanan Wang, and Li Li. A Case of Pagetoid Bowen’s Disease. Chinese Medical Journal, 2017 130 (24): 3023-3024.Yixin Luo, Jie Liu. Multiple plaques, slack skin, and ulcers. Journal of the American Academy Dermatology, 2016; 75(6): e203 – e206.Angela J. Argyropoulos, Patrick Robichaud, Rebecca Mutesi Balimunkwe, Gary J. Fisher, Craig Hammerberg, Yan Yan, Taihao Quan. Alterations of Dermal Connective Tissue Collagen in Diabetes: Molecular Basis of Aged-Appearing Skin. PLOS ONE Journal, 2016;11(4): e0153806Trupta Purohit, Tianyuan He, Zhaoping Qin, Ting Li, Gary J. Fisher, Yan Yan, John J. Voorhees, Taihao Quan. Smad3-dependent regulation of type I collagen in human dermal fibroblasts: Impact on human skin connective tissue aging. Journal of Dermatological Science, 2016; 83(1): 80-85.Barbara A. Gilchrest. Introduction to the JID Workshop in Shanghai. Journal of Investigative Dermatology Symposium Proceeding, 2015 17(1): 1-6.Jouni Uitto, Gang Wang. Molecular Genetics of Heritable Skin Diseases: Pseudoxanthoma Elasticum as a Paradigm of China-US Collaboration. Journal of Investigative Dermatology Symposium Proceeding, 2015; 17 (1): 20- 21.Liang Jin, Qiujie Jiang, Zhengsheng Wu, Changxia Shao, Yong Zhou, Luting Yang, Jouni Uitto and Gang Wang. Genetic Heterogeneity of Pseudoxanthoma Elasticum: The Chinese Signature Profile of ABCC6 and ENPP1 Mutations. Journal of Investigative Dermatology, 2015; 135 (5): 1294 – 1302.Meng Pan, Haiqin Zhu, Renchao Xu. Immune cellular regulation on autoantibody production in pemphigus. The Journal of Dermatology, 2015; 42 (1): 11 – 17.Stem Cell Research and Regenerative Medicine (Former: Hematology): 10Zheng Ge, Yan Gu, Qi Han, Justin Sloane, Qinyu Ge, Goufeng Gao, Jinlong Ma, Huihui Song, Jiaojiao Hu, Baoan Chen, Sinisa Dovat & Chunhua Song. Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia. Epigenomicts, 2018;10(1):59-69Xilian Zhou, Yan Gu, Qi Han, Mario Soliman, Chunhua Song, and Zheng Ge. Coexistence of EZH2, NOTCH1, IL7R, and PHF6 Mutations in Adult T-cell Acute Lymphoblastic Leukemia. Turkish Journal of Hematology, 2017; 34(4): 366 – 368.Xiaosu Zhao, Xiangyu Zhao, Mingrui Huo, Qiaozhen Fan, Xuying Pei, Yu Wang, Xiaohui Zhang, Lanping Xu, Xiaojun Huang, Kaiyan Liu, and Yingjun Chang. Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation. Journal of Immunology Research, 2017; 2017:1043836Yang Song, Yutong Wang, Xiaojun Huang, Yuan Kong. Abnormalities of the bone marrow immune microenvironment in patients with immune thrombocytopenia. Annals of Hematology, 2016; 95(6): 959 -965.Xiangyu Zhao, Feng Gao, Xiaohui Zhang, Yu Wang, Lanping Xu, Kaiyan Liu, Xiaosu Zhao, Yingjun Chang, Han Wei, Huan Chen, Yuhong Chen, Zhengfan Jiang, Xiaojun Huang. Improved clinical outcomes of rhG-CSF-mobilized blood and marrow haploidentical transplantation compared to propensity score-matched rhG-CSF-primed peripheral blood stem cell haploidentical transplantation: a multicenter study. Science China Life Sciences, 2016; 59 (11): 1149-1148.Yuan Kong, Yang Song, Yue Hu, Minmin Shi, Yutong Wang, Yu Wang, Xiaohui Zhang, Lanping Xu, Kaiyan Liu, Hongkui Deng, Xiaojun Huang. Increased reactive oxygen species and exhaustion of quiescent CD34-positive bone marrow cells may contribute to poor graft function after allotransplants. Oncotarget, 2016; 7(21): 30892 – 30906.Xiangyu Zhao, Xiaosu Zhao, Yutong Wang, Yingjun Chang, Lanping Xu, Xiaohui Zhang, Yu Wang, Yuhong Chen, Wei Han, Huan Chen, Chenhua Yan, Fengrong Wang, Jingzhi Wang, Yuqian Sun, Feifei Tang, Haixia Fu, Kaiyan Liu, Xiaojun Huang. Prophylactic use of low-dose interleukin-2 early post-transplantation: a randomized study. The Lancet, 2015; 386 (1): S7.Yingjun Chang, Xiangyu Zhao, Lanping Xu, Xiaohui Zhang, Yu Wang, Wei Han, Huan Chen, Fengrong Wang, Xiaodong Mo, Yuanyuan Zhang, Mingrui Huo, Xiaosu Zhao, Kong Yuan, Kaiyan Liu, and Xiaojun Huang. Donor-specific anti-human leukocyte antigen antibodies were associated with primary graft failure after unmanipulated haploidentical blood and marrow transplantation: a prospective study with randomly assigned training and validation sets. Journal of Hematology & Oncology, 2015; 8:84.Xiangyu Zhao, Xiaosu Zhao, Yutong Wang, Yingjun Chang, Lanping Xu, Xiaohui Zhang, Yu Wang, Yuhong Chen, Wei Han, Huan Chen, Chenhua Yan, Fengrong Wang, Jingzhi Wang, Yuqian Sun, Feifei Tang, Haixia Fu, Kaiyan Liu, Xiaojun Huang. Higher frequency of regulatory T cells in granulocyte colony-stimulating factor (G-CSF)-primed bone marrow grafts compared with G-CSF-primed peripheral blood grafts. Journal of Translational Medicine, 2015 13:145,Xiangyu Zhao, Yingjun Chang, Xiaosu Zhao, Lanping Xu, Xiaohui Zhang, Kaiyan Liu, Dan Li, Xiaojun Huang. Recipient expression of ligands for donor inhibitory KIRs enhances NK-cell function to control leukemic relapse after haploidentical transplantation. European Journal of Immunology, 2015;45(8):2396-408.Reproductive Medicine: 3Xin Chen, Shuxian Feng, Pingping Guo, Yuxia He, Yudong Liu, Desheng Ye, Shiling Chen. Does lower dose of long-acting triptorelin maintain pituitary suppression and produce good live birth rate in long down-regulation protocol for in-vitro fertilization. Journal of Huazhong University of Science and Technology [Medical Sciences], 2016; 36 (2): 215-220.Xin Chen, Yuan Huang, Pingping Guo, DeshengYe, Lijuan Xu, Shiling Chen. The association between serum β-hCG on day 24 of pregnancy and ongoing pregnancy in frozen embryo transfer cycles. International Journal of Gynecology & Obstetrics, 2016; 134 (3): 278 – 281.Xin Chen, Shiling Chen, Desheng Ye, Yudong Liu, Yuxia He, Xiaolong Tian, Lijuan Xu, Ting Tao. Retrospective analysis of reproductive outcomes in women with primary ovarian insufficiency showing intermittent follicular development. Reproductive Bio-Medicine Online. 2016; 32(4): 472-433.Translational Medicine: 3Gang Liu, Sen Liu, Mao Lin, Xiaoxin Li, Weisheng Chen, Yuzhi Zuo, Jiaqi Liu, Yuchen Niu, Sen Zhao, Bo Long, Zhihong Wu, Nan Wu, Guixing Qiu. Genetic polymorphisms of GPR126 are functionally associated with PUMC classifications of adolescent idiopathic scoliosis in a Northern Han population. Journal of Cellular and Molecular Medicine, 2018; 22(3):1964-1971.Gang Liu, Jia Chen, Yangzhong Zhou, Yuzhi Zuo, Sen Liu, Weisheng Chen, Zhihong Wu, Nan Wu. The genetic implication of scoliosis in osteogenesis imperfecta: a review. Journal of Spine Surgery, 2017; 3(4): 666-678.Jia Chen, Jiaqi Liu, Yangzhong Zhou, Sen Liu, Gang Liu, Yuzhi Zuo, Zhihong Wu, Nan Wu, Guixing Qiu. Molecular therapeutic strategies for FGFR3 gene-related skeletal dysplasia. Journal of Molecular Medicine, 2017; 95(12): 1303 – 1313《国内期刊发表的预防老年谵妄随机对照试验研究文献质量评价》 by YANG Lu, GAO Langli, YUE Jirong, and ZHANG Xuemei, Chin J Prac Nurs (《中国实用护理杂志》), June 21, 2015, Vol.31, No.18.《国内外老年患者围手术期谵妄的研究进展》by WANG Yanyan, YUE Jirong, and HU Xiuying, Chin J Prac Nurs (《中国实用护理杂志》), September 21 2015, Vol.31, No. 27.《我国老年谵妄预后队列研究的文献质量评价》(Assessment of Literature Quality of Cohort Studies of Delirium Prognosis of Elderly in China) by YANG Lu, YANG Jia, ZHANG Zemei, ZHANG Xuemei et all, Chinese Nursing Research, January, 2016 Vol. 30 No. 1A.《老年谵妄患者的循证护理》by GAO Langli, YANG Jia and YUE Jirong, West China Medical Journal (《华西医学》), Vol.31, No.7 Jul. 2016.《抗精神病药物治疗谵妄疗效和安全性的系统评价》by LIAO Yulin, YUE Jirong, XIE Dongmei, YANG Lu, DENG Chuanyao, GAO Lilang, and GENG Ting, 中国循证医学杂志, 2015, 15 (12): 1401~1406.《1例老年谵妄病人行多学科协作的HELP护理干预效果观察》by GAO Langli, PU Yusheng, and YUE Jirong, 《护理研究》2015年2月第29卷第2期中旬版 (总第493期).《预防老年住院患者谵妄发生的住院老年人生活项目干预模式的进展研究》by YANG Lu, YUE Jirong, and ZHANG Xuemei, Chin J Prac Nurs (《中国实用护理杂志》) July 11 2015, Vol.31, No.20.《老年病和老年研究的主要内容及其在中国的发展》by Leng Sean X, Chinese Journal of Geriatrics Research (Electronic Edition) 2015; 2:1-3.《老年人衰弱综合征的发病机制和评估及管理》by Xiaoxuan Ning, Min Ouyang, and Leng Sean X, Chinese Journal of Geriatrics 2015; 34:1282-5.《打破传统亚专科片段医疗服务模式: 引进现代老年医学观念》by Sean Leng, Chinese Journal of Geriatrics 2012; 31:7-20.