Dennis Roop, MD

Chair, Regenerative Medicine and Stem Cell Biology Program
University of Colorado

Dr. Roop received his received a B.A. degree in Biology from Berea College, Berea, and a M.S. and Ph.D. in Microbiology from the University of Tennessee, Knoxville, TN. He was a postdoctoral fellow with Dr. Bert O’Malley at Baylor College of Medicine, Houston, TX, from 1977 to 1980. Subsequently, he joined the laboratory of Dr. Stuart Yuspa at the National Cancer Institute, National Institutes of Health, Bethesda, MD, where he rose to the rank of Senior Investigator.

In 1988, he was recruited back to Baylor College of Medicine, where he held the positions of Professor of Molecular and Cellular Biology and Dermatology and Director of the Center for Cutaneous Molecular Biology until he was recruited to his current position in Colorado in 2007. He has served on the Advisory Council at the National Institute of Arthritis and Musculoskeletal and Skin Diseases and he is a former President of the Society for Investigative Dermatology. His laboratory has had a long-standing interest in epidermal stem cells, the role that they play in inherited skin diseases and the potential isolation and correction of defective epidermal stem cells and their use as autologous grafts to treat patients with these diseases. More recently, his research has focused on induced pluripotent stem cells (iPSCs). His laboratory is currently generating iPSCs from patients with inherited skin diseases using methods which do not require viral vectors, and determining whether zinc finger nucleases can be used to correct the genetic defect in these patient-specific iPSCs.