英文论文列表

老年病学

  • Joseph B. Margolick, Jay H. Bream, Tricia L. Nilles, Huifen Li, Susan J. Langan, Shane Deng, Ruibin Wang, Nikolas Wada, and Sean X. Leng,“ Relationship Between T-Cell Responses to CMV, Markers of Inflammation, and Frailty in HIV-uninfected and HIVinfected Men in the Multicenter AIDS Cohort Study”, The Journal of Infectious Diseases, 2018, 1-10.
  • Maryam Keshtkar-Jahromi, Min Ouyang , Marzieh Keshtkarjahromi, Samah Almed, Huifen Li, Jeremy D. Walston, Rebeca Rios, Sean X. Leng,“ Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults”, Vaccine, 36, Issu. 1612 April 2018, pp. 2220-2225. https://doi.org/10.1016/j.vaccine.2017.11.045
  • Jinlei Lie, Matthew Ogrodnik, Vijaya B. KolachalamadHonghuang Linand Rhoda Aub,“ Assessment of the Mid-Life Demographic and Lifestyle Risk Factors of Dementia Using Data from the Framingham Heart Study Offspring Cohort”, Journal of Alzheimer’s Disease 63, 2018, pp. 1119–1127. DOI 10.3233/JAD
  • Xiang Ding, Qiukui Hao, Ming Yang, Tie Chen, Shanping Chen, Jirong Yue, Sean X. Leng and Birong Dong, “Polymorphism rs189037C > T in the promoter region of the ATM gene may associate with reduced risk of T2DM in older adults in China: a case control study”, Ding et al. BMC Medical Genetics, vol. 18, no. 84, 2017, pp. 1-7.
  • Ding, Xiang MD, He, Yong MD, Hao, Qiukui MD, Chen, Shanping MD, Yang, Ming MD, Leng, Sean X. MD, PhD, Yue, Jirong MD, Dong, Birong MD, PhD, “The association of single nucleotide polymorphism rs189037C>T in ATM gene with coronary artery disease in Chinese Han populations: A case control study”, Medicine, vol. 97, no. 4, January 2018, pp. e974. doi: 10.1097/MD.000000000000974
  • Xinwen Zhang, MD, Xin Meng, MD, PhD, Yiyin Chen, MD, Sean X. Leng, MD, PhD, and Haiyan Zhang, MD, PhD “The Biology of Aging and Cancer Frailty, Inflammation, and Immunity” The CancerJournal, v23 , no. 4, July/August 2017, pp. 201 – 205
  • Mingfang Zhao, Hans Liu, Yanqing Tang, Xin Meng, Jun Yu, Qi Wang, Qiao Zhou, Sean X. Leng and Haiyan Zhang, “Clinicopathologic features and prognostic factors for patients with colorectal cancer who are 75 years and older”  Oncotarget, v 8, no. 45, October 2017, pp. 80002 – 80011. doi:  10.18632/oncotarget.20656
  • Jing Tang, Hans B. Liu, Lujiao Yu, Xin Meng, Sean X. Leng, Haiyan Zhang, “Clinical-pathological Characteristics and Prognostic Factors for Papillary Thyroid Microcarcinoma in the Elderly” Journal of Cancer, v , no. 2, Janurary 2018, pp. 256 -262. doi:  10.7150/jca.22700.
  • Junhong Zhou, On-Yee Lo, Lewis A. Lipsitz, Jue Zhang, Jing Fang, Brad Manor, “Transcranial direct current stimulation enhances foot sole somatosensation when standing in older adults”, Experimental Brain Research, January 2018, pp.1-8.
  • Qian-Li Xue,1,2 Huanle Yang,1 Hui-Fen Li,1 Peter M. Abadir,1 Tyesha N. Burks,1 Lauren G. Koch,3 Steven L. Britton,3,4 Joshua Carlson,1 Laura Chen,1 Jeremy D. Walston,1,2 and Sean X. Leng, “Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats” Aging, 8, no. 3 March 2016,pp. 769 – 776, 10.18632/aging.100929
  • Huifen Li Peter Weng, Kevin Najarroa, Qian-Li Xue, Richard D.Sembab, Joseph Margolick, Sean X.Leng, “Chronic CMV infection in older women: Longitudinal comparisons of CMV DNA in peripheral monocytes, anti-CMV IgG titers, serum IL-6 levels, and CMV pp65 (NLV)-specific CD8+ T-cell frequencies with twelve year follow-up”. Experimental Gerontology, vol. 54, June 2014, pp.84-89.
  • Sean X. Leng MD, PhD, Xiao-Ying Li MD, “Introduction of Abstracts to be Presented at the Fifth Chinese Congress on Gerontology and Health Industry” Journal of the American Geriatric Society, , vol. 64, no. s2, July 2016, pp. s315- s316.
  • Sean X. Leng MD, PhD, Xiao-Ying Li MD, “Introduction of Abstracts to be Presented at the Sixth Chinese Congress on Gerontology and Health Industry” Journal of the American Geriatric Society, Special Issue of Abstracts from the Sixth Chinese Congress on Gerontology and Health Industry, vol. 65, no. s2, September 2017, pp. s293- s294. DOI: 10.1111/jgs.15054
  • Gregory D. Kirk, Stewart Dandorf, Huifen Li, Yiyin Chen, Shruti H. Mehta, Damani A. Piggott, Joseph B. Margolick, and Sean X. Leng, “Differential Relationships among Circulating Inflammatory and Immune Activation Biomediators and Impact of Aging and Human Immunodeficiency Virus Infection in a Cohort of Injection Drug Users”. Frontiers in Immunology,vol. 8, October 2017, pp.1343. http://doi.org/10.3389/fimmu.2017.01343
  • Sean X. Leng, Jeremy Kamil, John G. Purdy, Niels A. Lemmermann, Matthias J. Reddehase, Felicia D. Goodrum, “Recent advances in CMV tropism, latency, and diagnosis during aging”. GeroScience,vol. 39, 2017, pp.251-259. DOI 10.1007/s11357-017-9985-7
  • X. Mao; H. F. Li; J. B. Margolick; G. F. Wang; S. X. Leng, “Cellular Senescence by Human Cytomegalovirus (CMV) Infection in Human Fibroblasts and Protective Effect from Resveratrol: P64”, Journal of the American Geriatrics Society, vol. 62, no. 1, September 2014, pp. s354 – s355.
  • Xiang Ding, Joseph B. Margolick, Sean X. Leng, “T-Cell Immunity against Cytomegalovirus in Older Adults”. Handbook of Immunosenescence, October 2017, DOI https://doi.org/10.1007/978-3-319-64597-1_123-1
  • Leng, X. Liu, J.B. Halter, “A CHINESE HOME CARE MODEL FOR FRAIL ELDERLY INTEGRATING GERIATRICS, HOME SERVICE, AND TECHNOLOGY”, Innovation in Aging, vol. 1, no.1, June 2017, Pages 1048–1049. https://doi.org/10.1093/geroni/igx004.3832
  • Liu, M. Zhu L. Kang, “THE ROLE OF GERIATRICS INTERDISCIPLINARY TEAM IN HOME CARE FOR THE FRAIL ELDERLY IN BEIJING, CHINA”, Innovation in Aging, vol.
  • 1, no.1, June 2017, Pages 1049. https://doi.org/10.1093/geroni/igx004.3834
  • Leng, M. Bellantoni M. McNabney  T. Finucane  W. Greeenough  L.P. Fried  S. Durso, “INTERNATIONAL COLLABORATION FOR GERIATRICS AND HOME CARE MODEL DEVELOPMENT IN CHINA”, Innovation in Aging, vol. 1, no.1, June 2017, Pages 1049. https://doi.org/10.1093/geroni/igx004.3833
  • Huifen Li, Genxiang Mao,  Joshua Carlson, Sean X.Leng, “A novel flow cytometry-based tool for determining the efficiency of human cytomegalovirus infection in THP-1 derived macrophages”, Journal of Virological Methods, vol. 221, no. 1, September 2015,   127 – 130. https://doi.org/10.1016/j.jviromet.2015.04.028
  • Genxiang Mao, Huifen Li, Xiang Ding, Xin Meng, Guofu Wang, Sean X. Leng, “Suppressive effects of sirtinol on human cytomegalovirus (hCMV) infection and hCMV-induced activation of molecular mechanisms of senescence and production of reactive oxygen species”, Mechanisms of Ageing and Development, vol. 158, January 2016, 62 – 69.
  • Xujiao Chen, Genxiang Mao, Sean X Leng, “Frailty syndrome: an overview”, Clinical Interventions in Aging, vol. 92014, 433-441.
  • Jirong Yue, Tammy T. Hshieh, Sharon K. Inouye, “Hospital Elder Life Program (HELP)”, Geriatrics Models of Care, 2015, pp. 25-37
  • Jinlei Li, Matthew Ogrodnik, Sherral Devine, Sanford Auerbach, Philip A. Wolf, Rhoda Au, “Practical risk score for 5-, 10-, and 20-year prediction of dementia in elderly persons: Framingham Heart Study” British Journal of Dermatology, v 14, no. 1, June 2017, pp. 35 – 42. DOI: https://doi.org/10.1016/j.jalz.2017.04.013
  • Sean X. Leng, MD, PhD, Jennie Chin Hansen RN, MS, FAAN, and Xiao-Ying Li MD, “Introduction of Abstracts to be Presented at the Second Chinese Congress on Gerontology and Health Industry” Journal of the American Geriatric Society, , vol. 61, no. s3 2013, pp. s307- s308.
  • Sean X. Leng, MD, PhD, Jennie Chin Hansen, and Xiao-Ying Li, MD, “Introduction of Abstracts to be Presented at the Third Chinese Congress on Gerontology and Health Industry” Journal of the American Geriatric Society, , vol. 62, 2014, pp. s333- s334.
  • Sean X. Leng MD, PhD, Xiao-Ying Li MD, “Introduction of Abstracts to be Presented at the Fourth Chinese Congress on Gerontology and Health Industry” Journal of the American Geriatric Society, , vol. 63, no. s2, September 2015, pp. s321- s322.
  • Sean X. Leng, Joseph B. Margolick, “Understanding Frailty, Aging, and Inflammation in HIV Infection” Current HIV/AIDS Reports, vol. 12, no. 1, March 2015, pp. 22 – 35. https://doi.org/10.1007/s11904-014-0247-3
  • Leng Sean X., Dandorf Stewart, Li Huifen, Carlson Joshua, Hui Jessica, Mehta Shruti H., Piggott Damani, Islam Salequl, Manwani Bhavish, and Kirk Gregory D. “Associations of Circulating Soluble Tumor Necrosis Factor-α Receptors 1 and 2 with Interleukin-6 Levels in an Aging Cohort of Injection Drug Users with or at High Risk for HIV Infection”. AIDS Research and Human Retroviruses. vol. 31, no. 12, November 2015, pp. 1257-1264. https://doi.org/10.1089/aid.2015.0134

皮肤病学

  • Yu Zhang, Yang Luo, Yue Han, Rong Tian, Wei Li, Xu Yao. “Non-bullous lesions as the first manifestation of bullous pemphigoid: A retrospective analysis of 181 cases”, The Journal of Dermatology, vol.44, no. 7, July 2017, pp. 742 -746.
  • Yixin Luo, MD, Jie Liu, MD, PhD, “Multiple plaques, slack skin, and ulcers” Journal of the American Academy Dermatology, v 75, no. 6, December 2016, pp. e203 – e206. DOI: https://doi.org/10.1016/j.jaad.2016.03.012
  • Luo, J. Liu, “Image Gallery: Verrucous porokeratosis with characteristic histopathological and dermoscopic feature” British Journal of Dermatology, vol. 176, no. 4, April 2017, pp. e38. DOI: 10.1111/bjd.15328
  • Chenchen Xu, Dan Zhou, Yixin Luo, Shuai Guo, Tao Wang, Jie Liu, Yuehua Liu and Zhili Li, “Tissue and serum lipidome shows altered lipid composition with diagnostic potential in mycosis fungoides” Oncotarget, v 8, no. 29, July 2017, pp. 48041 – 48050. doi: 10.18632/oncotarget.18228
  • Luo, J. Liu, “Image Gallery: Moth-eaten alopecia as the only cutaneous symptom of acquired secondary syphilis in a 2-year-old boy” British Journal of Dermatology, vol. 177, no. 5, November 2017, pp. e227. DOI: 10.1111/bjd.15957
  • Angela J. Argyropoulos, Patrick Robichaud, Rebecca Mutesi Balimunkwe, Gary J. Fisher, Craig Hammerberg, Yan Yan, Taihao Quan, “Alterations of Dermal Connective Tissue Collagen in Diabetes: Molecular Basis of Aged-Appearing Skin” PLOS ONE Journal, April 2016, https://doi.org/10.1371/journal.pone.0153806
  • Trupta Purohit, Tianyuan He, Zhaoping Qin, Ting Li, Gary J. Fisher, Yan Yan, John J. Voorhees, Taihao Quan, “Smad3-dependent regulation of type I collagen in human dermal fibroblasts: Impact on human skin connective tissue aging” Journal of Dermatological Science, v83,no. 1, July 2016, pp. 80-85.
  • Tian Zhu, Tao Wang, Dong-Lai Ma, Ya-Nan Wang, and Li Li, “A Case of Pagetoid Bowen’s Disease”, Chinese Medical Journal, v130, no. 24, December 2017, pp. 3023-3024.
  • Zhu, D.L. Ma, Y.P. Zeng, L. Song, L. Li, “Bullous pemphigoid associated with silicosis”, Journal of the European Academy of Dermatology and Venereology, vol. 32, no. 1, January 2018, pp. e1-e2.
  • Barbara A. Gilchrest, “Introduction to the JID Workshop in Shanghai” Journal of Investigative Dermatology Symposium Proceeding, 17, no. 1, July 2015, pp. 1-6.
  • Jouni Uitto, Gang Wang, “Molecular Genetics of Heritable Skin Diseases: Pseudoxanthoma Elasticum as a Paradigm of China-US Collaboration”, Journal of Investigative Dermatology Symposium Proceeding, vol. 17, no. 1, July 2015, pp. 20- 21.
  • Liang Jin, Qiujie Jiang, Zhengsheng Wu, Changxia Shao, Yong Zhou, Luting Yang, Jouni Uitto and Gang Wang, “Genetic Heterogeneity of Pseudoxanthoma Elasticum:The Chinese Signature Profile of ABCC6 and ENPP1 Mutations”, Journal of Investigative Dermatology, vol. 135, no. 5, May 2015, pp. 1294 – 1302.
  • Meng PAN, Haiqin ZHU, Renchao XU, “Immune cellular regulation on autoantibody production in pemphigus”, The Journal of Dermatology, vol. 42, no. 1, Janurary 2015, pp. 11 – 17. DOI: 10.1111/1346-8138.12697

血液病学

  • Xiangyu Zhao, Xiaosu Zhao, Yutong Wang, Ying-Jun Chang, Lan-Ping Xu, Xiao-Hui Zhang, Yu Wang, Yu-Hong Chen, Wei Han, Huan Chen, Chen-Hua Yan, Feng-Rong Wang, Jing-Zhi Wang, Yu-Qian Sun, Fei-Fei Tang, Hai-Xia Fu, Kai-Yan Liu, Prof Xiao-Jun Huang, “Prophylactic use of low-dose interleukin-2 early post-transplantation: a randomised study” The Lancet, v386 ,no. 1, October 2015, pp. S7.
  • Xiangyu Zhao, Feng Gao, Xiaohui Zhang, Yu Wang, Lanping Xu, Kaiyan Liu, Xiaosu Zhao, Yingjun Chang, Han Wei, Huan Chen, Yuhong Chen, Zhengfan Jiang, Xiaojun Huang, “Improved clinical outcomes of rhG-CSF-mobilized blood and marrow haploidentical transplantation compared to propensity score-matched rhG-CSF-primed peripheral blood stem cell haploidentical transplantation: a multicenter study” Science China Life Sciences, v59, no. 11, November 2016, pp 1149-1148, DOI:https://doi.org/10.1007/s11427-016-0014-8
  • Xiaosu Zhao, Xiangyu Zhao, Mingrui Huo,  Qiaozhen Fan,  Xuying Pei,  Yu Wang,  Xiaohui Zhang, Lanping Xu,  Xiaojun Huang,  Kaiyan Liu,  and Yingjun Chang, “Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation” Journal of Immunology Research, v 2017, 2017, https://doi.org/10.1155/2017/1043836
  • Yang Song, Yu-Tong Wang, Xiao-Jun Huang, Yuan Kong, “Abnormalities of the bone marrow immune microenvironment in patients with immune thrombocytopenia”, Annals of Hematology, v95, no. 6, May 2016, pp. 959 -965.
  • Yuan Kong, Yang Song, Yue Hu, Min-Min Shi, Yu-Tong Wang, Yu Wang, Xiao-Hui Zhang, Lan-Ping Xu, Kai-Yan Liu, Hong-Kui Deng, Xiao-Jun Huang, “Increased reactive oxygen species and exhaustion of quiescent CD34-positive bone marrow cells may contribute to poor graft function after allotransplants”, Oncotarget, v7, no. 21, May 2016, pp. 30892 – 30906.
  • Zheng Ge, Yan Gu, Qi Han, Justin Sloane, Qinyu Ge, Goufeng Gao, Jinlong Ma, Huihui Song, Jiaojiao Hu, Baoan Chen, Sinisa Dovat & Chunhua Song “Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia”, Epigenomicts, v10, no. 1, October 2017 https://doi.org/10.2217/epi-2017-0092
  • Xilian Zhou, Yan Gu, Qi Han, Mario Soliman, Chunhua Song, and Zheng Ge “Coexistence of EZH2, NOTCH1, IL7R, and PHF6 Mutations in Adult T-cell Acute Lymphoblastic Leukemia”, Turkish Journal of Hematology, v34, no. 4, December 2017, pp. 366 – 368. 10.4274/tjh.2017.0194
  • Ying-Jun Chang, Xiang-Yu Zhao, Lan-Ping Xu, Xiao-Hui Zhang, Yu Wang, Wei Han, Huan Chen, Feng-Rong Wang, Xiao-Dong Mo, Yuan-Yuan Zhang, Ming-Rui Huo, Xiao-Su Zhao, Kong Y, Kai-Yan Liu, and Xiao-Jun Huang, “Donor-specific anti-human leukocyte antigen antibodies were associated with primary graft failure after unmanipulated haploidentical blood and marrow transplantation: a prospective study with randomly assigned training and validation sets” Journal of Hematology & Oncology, v8 no.84, 2015, https://doi.org/10.1186/s13045-015-0182-9
  • Xiangyu Zhao, Xiaosu Zhao, Yutong Wang, Ying-Jun Chang, Lan-Ping Xu, Xiao-Hui Zhang, Yu Wang, Yu-Hong Chen, Wei Han, Huan Chen, Chen-Hua Yan, Feng-Rong Wang, Jing-Zhi Wang, Yu-Qian Sun, Fei-Fei Tang, Hai-Xia Fu, Kai-Yan Liu, Prof Xiao-Jun Huang, “Higher frequency of regulatory T cells in granulocyte colony-stimulating factor (G-CSF)-primed bone marrow grafts compared with G-CSF-primed peripheral blood grafts” Journal of Translational Medicine, 2015 13:145,
  • Xiang-Yu Zhao, Ying-Jun Chang, Xiao-Su Zhao, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Dan Li, Xiao-Jun Huang, “Recipient expression of ligands for donor inhibitory KIRs enhances NK-cell function to control leukemic relapse after haploidentical transplantation” Eurpean Jouranl of Immunlogy, 45 no.8 pp.2396 -2408.

生殖医学

  • Xin Chen, Shu-xian Feng, Ping-ping Guo, Yu-xia He, Yu-dong Liu, De-sheng Ye, Shi-ling Chen, “Does lower dose of long-acting triptorelin maintain pituitary suppression and produce good live birth rate in long down-regulation protocol for in-vitro fertilization?” Journal of Huazhong University of Science and Technology [Medical Sciencess], v36, no. 2, April 2016, pp. 215-220.
  • Xin Chen, Yuan Huang, Ping-Ping Guo, De-ShengYe, Li-Juan Xu, Shi-Ling Chen, “The association between serum β-hCG on day 24 of pregnancy and ongoing pregnancy in frozen embryo transfer cycles” International Journal of Gynecology & Obstetrics, v134 ,no. 3, September 2016, pp. 278 – 281.
  • Xin Chen, Shi-Ling Chen, De-Sheng Ye, Yu-Dong Liu, Yu-Xia He, Xiao-Long Tian, Li-Juan Xu, Ting Tao, “Retrospective analysis of reproductive outcomes in women with primary ovarian insufficiency showing intermittent follicular development” Reproductive BioMedicine Online. v32, 2016, pp. 472-433.

转化医学

  • Gang Liu, Jia Chen, Yangzhong Zhou, Yuzhi Zuo , Sen Liu, Weisheng Chen, Zhihong Wu, Nan Wu, “The genetic implication of scoliosis in osteogenesis imperfecta: a review”, Journal of Spine Surgery, v3, no. 4, December 2017, pp. 666-678. doi:  10.21037/jss.2017.10.01
  • Jia Chen, Jiaqi Liu, Yangzhong Zhou, Sen Liu, Gang Liu, Yuzhi Zuo, Zhihong Wu, Nan Wu, Guixing Qiu, “Molecular therapeutic strategies for FGFR3 gene-related skeletal dysplasia”, Journal of Molecular Medicine, v95, no. 12, December 2017, pp. 1303 – 1313. https://doi.org/10.1007/s00109-017-1602-9
  • Gang Liu, Sen Liu, Mao Lin, Xiaoxin Li, Weisheng Chen, Yuzhi Zuo, Jiaqi Liu, Yuchen Niu, Sen Zhao, Bo Long, Zhihong Wu, Nan Wu, Guixing Qiu, “Genetic polymorphisms of GPR126 are functionally associated with PUMC classifications of adolescent idiopathic scoliosis in a Northern Han population”, Journal of Cellular and Molecular Medicine, January 2018. DOI: 1111/jcmm.13486

中文论文列表

  • 《国内期刊发表的预防老年谵妄随机对照试验研究文献质量评价》 by YANG Lu, GAO Langli, YUE Jirong, and ZHANG Xuemei, Chin J Prac Nurs (《中国实用护理杂志》), June 21, 2015, Vol.31, No.18.
  • 《国内外老年患者围手术期谵妄的研究进展》by WANG Yanyan, YUE Jirong, and HU Xiuying, Chin J Prac Nurs (《中国实用护理杂志》), September 21 2015, Vol.31, No. 27.
  • 《我国老年谵妄预后队列研究的文献质量评价》(Assessment of Literature Quality of Cohort Studies of Delirium Prognosis of Elderly in China) by YANG Lu, YANG Jia, ZHANG Zemei, ZHANG Xuemei et all, Chinese Nursing Research, January, 2016 Vol. 30 No. 1A.
  • 《老年谵妄患者的循证护理》by GAO Langli, YANG Jia and YUE Jirong, West China Medical Journal (《华西医学》), Vol.31, No.7 Jul. 2016.
  • 《抗精神病药物治疗谵妄疗效和安全性的系统评价》by LIAO Yulin, YUE Jirong, XIE Dongmei, YANG Lu, DENG Chuanyao, GAO Lilang, and GENG Ting, 中国循证医学杂志, 2015, 15 (12): 1401~1406.
  • 1例老年谵妄病人行多学科协作的HELP护理干预效果观察》by GAO Langli, PU Yusheng, and YUE Jirong, 护理研究》20152月第29卷第2期中旬版 (总第493).
  • 预防老年住院患者谵妄发生的住院老年人生活项目干预模式的进展研究》by YANG Lu, YUE Jirong, and ZHANG Xuemei, Chin J Prac Nurs (《中国实用护理杂志》) July 11 2015, Vol.31, No.20.
  • 《老年病和老年研究的主要内容及其在中国的发展》by Leng Sean X, Chinese Journal of Geriatrics Research (Electronic Edition) 2015; 2:1-3.
  • 《老年人衰弱综合征的发病机制和评估及管理》by Xiaoxuan Ning, Min Ouyang, and Leng Sean X, Chinese Journal of Geriatrics 2015; 34:1282-5.
  • 《打破传统亚专科片段医疗服务模式: 引进现代老年医学观念》by Sean Leng, Chinese Journal of Geriatrics 2012; 31:7-20.